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Camptothecine Powder<o:p></o:p>
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Active Ingredients: Camptothecine
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Specification: 92%、95%、98% Camptothecine by HPLC 
<o:p></o:p>
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Appearance: Light yellow or crystalline powder<o:p></o:p>
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Botanical Source: Fruit
or leaf of Camptotheca acuminata Decne<o:p></o:p>
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Molecular
Formula: C20H16N204<o:p></o:p>
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Molecular Mass: 348.36<o:p></o:p>
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CAS No.: <st1:chsdate year="7689" month="3" day="4" islunardate="False" isrocdate="False" w:st="on">7689-3-4</st1:chsdate><o:p></o:p>
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<o:p>&nbsp;<img src="/images/Camptothecine Powder.JPG" title="Camptothecine Powder" alt="Camptothecine Powder" /></o:p>
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Main Function<o:p></o:p>
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Camptothecin is an alkaloid derived from the chinese tree
Camptotheca acuminata Decne. Camptothecin and its derivatives are unique in
their ability to inhibit DNA Topoisomerase I, by stabilizing a covalent
reaction intermediate termed the cleavable complex which ultimately causes
tumor cell death. In clinical it is widely believed that camptothecin analogs
exhibited remarkable anti-tumour and anti-leukaemia activity.&nbsp;
Topoisomerase is
a basilic enzyme in the process of DNA replication, it is responsible for the
winding / unwinding of the supercoiled DNA composing the chromosomes. If the
chromosomes cannot be unwound, transcription of DNA message cannot occur and
the protein cannot be synthesized, it ultimately causes cell death. Application
of camptothecin in clinic is limited due to serious side effects and poor
water-solubility.&nbsp;
At present, some camptothecin analogs, either semi-synthetic
or synthetic drug based on camptothecin, have been applied cancerous therapy
such as topotecan and irinotecan while others have been obtained satisfying
curative effects in clinic. <o:p></o:p>
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Application:<o:p></o:p>
-Treatment Gastrointestinal cancer and leukemia,
-Plant growth regulator activity and kill insects.&nbsp; 
-Treatment of gastric cancer, liver cancer, head and neck cancer and
leukemia,, with fewer side effects than camptothecine.
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